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Notably, this dimeric species was highly resistant to reduction and disappeared only after heating at 90 °C in the presence of β -mercaptoethanol, suggesting that the higher-order oligomers are assembled from exceptionally stable, disulfide-crosslinked dimers

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6 The damage caused by AβOs to mitochondria Mitochondrial dysfunction is one of the primary markers of neuronal toxicity induced by AβO in the pathogenesis of AD